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Nonalcoholic fatty liver disease (NAFLD): People who drink little to no alcohol can develop a range of liver conditions called NAFLD

Pehar M, Vargas MR, Robinson KM, Cassina P, Diaz-Amarilla PJ, Hagen TM, et al

Briefly, cells were seeded in 96-well plates at 310 3 cells per well

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Upon extensive DNA damage, hyperactivation of PARP rapidly depletes cellular NAD+ pools, thereby compromising the cells antioxidant buffering capacity [100]

In accordance with the results of the enrichment analysis, a selection of representative proteins implicated in the mitogen-activated protein kinase (MAPK) and Ras-associated protein 1 (Rap1) signaling pathways was chosen for validation